Dr. Matshidiso Moeti has had a long and distinguished career in public health and is currently serving her second term as the World Health Organization (WHO) Regional Director for Africa. Breaking new ground as the first woman to ever hold this position, Dr. Moeti led the WHO’s response to the Ebola outbreak in West Africa during her first term in the position. Prior to joining the WHO, Dr. Moeti worked on curbing the HIV/AIDS epidemic, first as the Head of the HIV/AIDS Unit in the Ministry of Health of Botswana, her home country, then with the Joint United Nations Programme on HIV/AIDS (UNAIDS) as Team Leader of the Africa and Middle East Desk in Geneva, then as head of the WHO Regional Office for Africa’s HIV/AIDS program. Most recently, Dr. Moeti has been working throughout the COVID-19 pandemic to connect leaders across the African continent and develop a coordinated response. Dr. Moeti’s COVID-19 response efforts have clearly made an impression on her staff and colleagues. Out of all the nominations we received during our “Spotlight a COVID-19 Heroine” campaign, more than one third were for Dr. Moeti. The nominations came from a total of 25 different countries across Africa. This is, by far, the largest number of nominations received for one nominee and from the widest geographic scope, reflecting the profound impact Dr. Moeti has had on the continent as a whole in her role as WHO Regional Director.